Bupropion and alcohol: Mixing risks, side effects, and more

wellbutrin and alcohol

Sometimes, doctors prescribe it to treat bipolar disorder or a related mental health condition. Under the brand Zyban, bupropion helps with smoking cessation (nicotine replacement). Bupropion is used to treat depression and to prevent depression in patients with seasonal affective disorder (SAD), which is sometimes called winter depression. It is also used as part of a support program to help people stop smoking.

You should refer to the prescribing information for Wellbutrin for a complete list of interactions. The easiest way to lookup drug information, identify eco sober house price pills, check interactions and set up your own personal medication records. If you happen to miss a dose of bupropion, take it as soon as you remember.

This usually refers to drugs prescribed to treat conditions such as attention deficit hyperactivity disorder (ADHD) and narcolepsy. If you recently suddenly stopped using alcohol or certain drugs. Your risk of a seizure with Wellbutrin may be higher if you’ve recently stopped taking certain drugs, including a benzodiazepine, barbiturate, or epilepsy drug. This risk may also be higher if you’ve suddenly stopped drinking alcohol (and you used to drink regularly or excessively). You should not take Wellbutrin if you’ve recently stopped using alcohol or one of these drugs suddenly.

wellbutrin and alcohol

If the CYP2D6 enzyme is less active than usual, the antidepressant may not break down in your body correctly. This can increase the level of the antidepressant in your system. With more of the antidepressant in your body than usual, side effects of the drug may be more frequent or severe.

People should always discuss any current medications with a healthcare professional before taking bupropion. Current medications include any vitamins, supplements, and herbal remedies they may take or plan to take. If a person taking Wellbutrin feels they cannot stop drinking alcohol, they should speak with a medical professional. This article explores the risks of mixing Wellbutrin and alcohol, including other side effects. It also includes managing substance misuse and other treatments for depression. Wellbutrin contains an active ingredient called bupropion and belongs to a drug class known as aminoketone.

Interaction with certain diabetes drugs

For this reason, it’s still important to check with your doctor or pharmacist before taking any of these products while taking Wellbutrin. If you have questions about interactions that may affect you, talk with your doctor or pharmacist. If you experience a seizure while taking Wellbutrin and a stimulant drug, your doctor will likely have you stop taking Wellbutrin, the stimulant, or both medications. (Wellbutrin is an antidepressant.) These interactions occur for different reasons, depending on the drug. If you have other questions about alcohol and your Wellbutrin treatment, talk with your doctor or pharmacist. Because of this risk, doctors will avoid prescribing Wellbutrin with an MAOI.

If you have any underlying conditions, they should be closely monitored by a qualified healthcare provider while you are taking Wellbutrin. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use wellbutrin only for the indication prescribed. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. There are 491 drug interactions with Wellbutrin (bupropion). Your healthcare provider may prescribe a modified dosage of Wellbutrin due to possible side effects or another health concern. Wellbutrin can be present in breast milk, so caution should be used by people who are breastfeeding.

Keep in mind that this chart does not include all drugs that may interact with Wellbutrin. For more information about some of these interactions, see the “Drug interactions explained” section below. Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements. Bupropion at one point was removed from the market during the late 1980s over the concern of drug-induced seizures.


To reduce a person’s risk of seizures and other side effects, it is a good idea to avoid any amount of alcohol while taking Wellbutrin. Mixing Wellbutrin with alcohol increase the risk of alcohol poisoning. Taking Wellbutrin while drinking lowers your alcohol tolerance and causes you to become severely intoxicated, even after drinking small amounts of alcohol.

Get started with our free assessment, which will tell you in minutes if treatment could be a good fit. If yes, we’ll connect you right to a clinician who can prescribe medication and have it shipped right to your door. Most people start on a lower dose, which doctors increase if needed. This happens because alcohol increases how much dopamine is in the brain. Wellbutrin can be an effective way to treat major depressive disorder (MDD) and seasonal affective disorder (SAD). If you have questions about receiving vaccines during treatment, talk with your doctor or pharmacist.

  • If you have other questions about Wellbutrin and MAOIs, talk with your doctor or pharmacist.
  • The doctor will evaluate a person’s symptoms and drinking lifestyle to determine the best treatment to reduce their risk of side effects.
  • There is help available in the form of drug and alcohol addiction treatment program options.
  • Sudden discontinuance of alcohol by chronic drinkers can increase the risk of seizures during Wellbutrin treatment.
  • However, some patients experience allergic reactions such as itching, swelling of the face, tongue, or throat, dizziness, trouble breathing, or skin rash.

To minimize your risk of having a seizure or other severe side effects while taking Wellbutrin, it’s crucial that you’re honest with your doctor about your drinking habits. If you regularly drink a lot of alcohol or have alcohol use disorder, abruptly stopping can lead to alcohol withdrawal syndrome. This is a potentially life-threatening condition if not properly managed. Medical experts consider Wellbutrin safe when used as directed and not mixed with alcohol, other medications, or drugs not approved by your doctor.

Side effects of mixing the two

The contraindications of Wellbutrin include the ones mentioned below. For additional information about Wellbutrin, including details https://sober-home.org/ about its uses, see this article. If you still have questions about Wellbutrin and its possible interactions, talk with your doctor.

wellbutrin and alcohol

The dose of this medicine will be different for different patients. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. Use only the brand of this medicine that your doctor prescribed. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. Left untreated, anaphylaxis can lead to organ failure and death.


It is also used to help people quit smoking and may be prescribed off-label for ADHD, weight loss, and bipolar disorder. It belongs to a class of medications known as aminoketones or norepinephrine-dopamine reuptake inhibitors (NDRIs). Unfortunately, however,  your drinking habits can affect how certain medications work and possibly put you at risk for serious side effects.

Effects of Alcohol on Depression

Daniel Kraciun, Operations VP/CMO at Trust.med, ensuring the integrity of pharmaceutical product data in the global healthcare supply chain. The World Health Organization used to define “moderate use” as up to one standard drink per day for women and up to two standard drinks for men. Today, the Organization isn’t so sure there is a level of alcohol that is safe for the human body. The lines become further blurred when genetics come into play. If you are already taking medicine for depression or to help you stop smoking, discuss this with your doctor before taking bupropion.

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You can ask your doctor about other treatments that may be better options for you. Certain health conditions or other factors could raise your risk of harm if you take Wellbutrin. In such cases, your doctor may not prescribe Wellbutrin for you. Doctors usually prescribe it for the treatment of depression, although they may also recommend it for individuals with SAD or to help a person stop smoking.

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